Role of Lymphoid Cells in Passive Transfer with Plasma of Delayed Hypersensitivity in Guinea Pigs

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Abstract
Specific skin reactions to purified protein derivatives could frequently be transferred with plasma or serum from heavily irradiated sensitized guinea pigs. Splenic lymphocytes from a non-sensitized animal that had been incubated for 90 minutes with plasma capable of transferring sensitivity became able to effect such a transfer. Latex particles, red blood cells, or thymocytes could not effect the transfer nor could spleen cells treated in vitro with large amounts of mitomycin C. It is concluded that only certain lymphoid cells may have receptors at their surfaces for attachment of the factor that is responsible for transferring sensitivity, and that the viability and the ability of these cells to replicate are essential for the passive transfer of delayed hypersensitivity.

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