MicroRNA Silencing in Primates: Towards Development of Novel Therapeutics
- 15 January 2009
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 69 (2) , 393-395
- https://doi.org/10.1158/0008-5472.can-08-2749
Abstract
MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic intervention. Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such compounds in the development of miRNA-based cancer therapeutics. [Cancer Res 2009;69(2):393–5]Keywords
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