Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.
- 1 November 1992
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 89 (21) , 10331-10335
- https://doi.org/10.1073/pnas.89.21.10331
Abstract
A splice variant of the metabotropic glutamate receptor (mGluR) 1a, named mGluR1c, was isolated. Compared to mGluR1a, the predicted mGluR1c protein is 302 amino acids shorter at its C-terminal end. Despite this difference, mGluR1c activates phospholipase C in Xenopus oocytes with a pharmacological profile identical to that of mGluR1a. However, in contrast to the large fast transient responses induced by mGluR1a, mGluR1c receptors elicit a small more slowly generated long-lasting oscillatory current, suggesting that these two receptors do not generate the same pattern of Ca2+ release in Xenopus oocytes. In situ hybridization data show that mGluR1c mRNA is expressed at a lower level than the other splice variants of mGluR1. Some differences in the regional distribution of these transcripts were observed in the cerebellum, the olfactory bulb, and the striatum.Keywords
This publication has 31 references indexed in Scilit:
- Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunitNeuron, 1992
- A family of metabotropic glutamate receptorsNeuron, 1992
- Activation of a Large‐conductance Ca2+‐Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide‐coupled Receptors in Cultured Cerebellar Granule CellsEuropean Journal of Neuroscience, 1991
- Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat BrainScience, 1991
- The rodent B2 sequence can affect expression when present in the transcribed region of a reporter geneGene, 1991
- Quisqualate receptor-mediated depression of calcium currents in hippocampal neuronsNeuron, 1990
- Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial SignalingScience, 1990
- The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous SystemAnnual Review of Pharmacology and Toxicology, 1989
- Structure of the Adrenergic and Related ReceptorsAnnual Review of Neuroscience, 1989
- A potential role for RNA transcribed from B2 repeats in the regulation of mRNA stabilityCell, 1987