Does High-Dose Ascorbic Acid Accelerate Renal Failure?

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Abstract
To the Editor: High-dose (200 mg per kilogram of body weight per day) ascorbic acid therapy was shown by Schneider et al. to be ineffective in children with nephropathic cystinosis.1 In that study, several lines of evidence suggested that renal insufficiency progressed more rapidly in children treated with ascorbic acid than in controls, although the study was discontinued before these trends reached statistical significance (P = 0.08). We have treated an infant with congenital nephrotic syndrome who had an abrupt loss of renal function coincident with the administration of high doses of ascorbic acid by her parents without her physicians' . . .

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