Inhibitory Effects of Estrogens on the Testosterone-Dependent Process of Sex Accessory Fructose Secretion

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Abstract
The simultaneous injections (sc) of testosterone (50 or 400 [mu]g/mouse/ day x10) and various estrogens (estradiol benzoate, ethynyl estra-diol or diethylstilbestrol) generally resulted in a lowering of both seminal vesicle and anterior prostate fructose levels. Low dose schedules (25 [mu]g daily xlO) of estradiol benzoate, ethynyl estradiol, estrone or estriol in the presence of testosterone (50 [mu]g daily x 10) exhibited similar antagonistic activities on fructose levels of mouse sex accessory organs. Intermediate or higher dose schedules (100 or 200 [mu]g daily x 10) of ethynyl estradiol plus testosterone (50 [mu]g series) were more effective in reducing fructose levels than were comparable amounts of estradiol benzoate, estriol or estrone. Estradiol benzoate (25 [mu]g) plus testosterone (400 [mu]g series) was more effective in lowering fructose than was ethynyl estradiol, estrone or estriol. In the 400 [mu]g testosterone series, intermediate or higher dosages (100 and 200 [mu]g, respectively) of estrogens revealed ethynyl estradiol > estradiol benzoate > estradiol > estrone in antagonizing sex acces -sory fructose levels in the castrate mouse. Diethylstilbestrol (5, 10, 25, 50 or 100 [mu]g daily x 10) caused a lowering of fructose levels in testosterone-treated (50 or 400 [mu]g series) castrate mice.