PERMANENT DAMAGE TO THE NERVOUS SYSTEM FOLLOWING AN ATTACK OF POLYRADICULONEURITIS (GUILLAIN-BARRÉ SYNDROME)
- 1 June 1943
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 49 (6) , 895-903
- https://doi.org/10.1001/archneurpsyc.1943.02290180119012
Abstract
Polyradiculoneuritis is a well recognized neurologic syndrome characterized by widespread motor and sensory signs pointing to involvement of the spinal and cranial nerves (most commonly the seventh cranial nerve). The definitely increased protein content of the cerebrospinal fluid without any change in the number of cells (albuminocytologic dissociation) is regarded as characteristic of the disorder and an important diagnostic feature. On the basis of the clinical symptoms the disease appears to be a distinct entity, but no etiologic agent has been established. That a virus is the causative agent has been repeatedly suspected, and an early report1described transmission of the disease to monkeys. All subsequent work, however, has failed to substantiate this earlier claim, although the idea that the syndrome is an acute infectious disease generally prevails.2 Clinically, polyradiculoneuritis is characterized by the onset of progressively severe neurologic signs and symptoms, which may continue to a fatalKeywords
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