The Place of BCG Vaccine in the Management of Infants Born of Tuberculous Mothers

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Abstract
One hundred and five infants, born of tuberculous mothers, have been followed a mean of 11 years. Thirty received BCG vaccine; all are alive, and none contracted tuberculosis. Of 75 nonvaccinated infants, 38 became infected with tuberculosis; six died (two with tuberculous meningitis, one with acute gastroenteritis and inactive pulmonary tuberculosis and three with nontuberculous disease). This experience and the known inadequacies of an imperfectly followed regimen of simple isolation, surveillance or isoniazid prophylaxis combine to make BCG vaccination the method of choice for prevention of tuberculosis in newborn infants of tuberculous mothers.

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