Electroencephalographic and Behavioral Effects of Tofrānil

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Abstract
Intravenous administration of Tofrānil in 28 voluntary, open-ward psychiatric patients elicited electrographic patterns of desynchronization and an increase of theta rhythms, associated with behavioral alerting, relaxation and lassitude. Chronic administration of oral Tofrānil in 16 depressed and retarded psychiatric subjects elicited behavioral adaptations of euphoric denial in eight, restlessness and somatization in three and no change in five. During the fifth week of administration, electrographic desynchronization was manifest. It is concluded that Tofrānil is an active central nervous system agent, with a spectrum of activity most like experimental anticholinergic hallucinogens. The theoretic significance for neurophysiologic-behavioral constructs is briefly discussed.

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