Fetal Anesthetic Requirement (MAC) for Halothane

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Abstract
-min intervals. We concomitantly obtained arterial blood from previously implanted catheters. When fetal movement in response to clamping the foot ceased, halothane was discontinued and the stimulus and sampling continued until the fetus began to move. Anesthesia was again resumed and continued until movement stopped. Anesthesia was then deepened and MAC was determined in the mother (stimulus—ear clamp). The fetal blood concentrations of halothane at MAC were 48 ± 28 mg/L; they were 133 ± 5 mg/L in the mother. This difference was highly significant (P < 0.001). Calculated end-tidal concentrations were 0.33% and 0.69%, respectively. In two animals delivered by cesarean section, MAC increased progressively over the first 12 h of life. Progesterone levels concomitantly decreased. Reprint requests to Dr. Gregory, Department of Anesthesia, University of California Room S426, Third and Parnassus Avenues, San Francisco, CA 94143. Presented in part at the annual meeting of the International Anesthesia Research Society, Atlanta, Georgia, 1981. Accepted for publication August 18, 1982. © 1983 International Anesthesia Research Society...

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