Morphogen gradient interpretation
Top Cited Papers
- 1 October 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 413 (6858) , 797-803
- https://doi.org/10.1038/35101500
Abstract
A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.Keywords
This publication has 48 references indexed in Scilit:
- Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila EmbryosCell, 2001
- Shaping Morphogen GradientsCell, 2001
- Dpp Gradient Formation in the Drosophila Wing Imaginal DiscCell, 2000
- The establishment of spemann's organizer and patterning of the vertebrate embryoNature Reviews Genetics, 2000
- Gradient Formation of the TGF-β Homolog DppCell, 2000
- Morphogen gradients: new insights from DPPTrends in Genetics, 1999
- Problems and paradigms: Morphogens and pattern formationBioEssays, 1997
- Morphogens, Compartments, and Pattern: Lessons from Drosophila?Cell, 1996
- Morphogens in vertebrate development: How do they work?BioEssays, 1995
- The bicoid protein determines position in the Drosophila embryo in a concentration-dependent mannerPublished by Elsevier ,1988