STUDIES IN GLANDULAR METABOLISM

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Abstract
After having observed that the percentages of total carbohydrates were approximately the same in each of 3 pairs of testicles and 4 pairs of submaxillary glands of dogs, a study was made of the effect of incubation on the glycogen, intermediary carbohydrate, and lactic acid contents of these glands. Sixteen pairs of excised testicles and 4 pairs of excised submaxillary glands were compared, 1 gland being subjected to glycolysis and the other frozen immediately upon removal. In most instances there was no change in intermediary carbohydrates following glycolysis. Experiments (5), however, offer evidence that incubation may increase the intermediary carbohydrate content to a slight though definite extent. In 5 cases a quantitative relationship was found between the decrease of glycogen and the production of lactic acid; in 9 experiments the decrease of glycogen, though marked, was less than the increase of lactic acid; in 4 other observations the glycogen, which was low in both glands, was unchanged on incubation; and in 2 cases the loss of glycogen was even greater than the increase of lactic acid. The fact that most of the observations showed a decrease of glycogen indicates that this substance is the source of part if not all of the lactic acid formed on the incubation of the testicle and the submaxillary gland.

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