Immunodiffusion Reactions with Rubella Antigens

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Abstract
Summary: Immune precipitates were demonstrable in gel double diffusion tests with the viral and soluble antigens of rubella using agarose and a “chamber” technique employing a plastic matrix over a thin layer of gel. Soluble antigens gave heavier lines of precipitate than did viral antigens, possibly due to better diffusion of the smaller antigen. The immunologic relationship between viral (large-particle) and soluble (small-particle) antigens which was suggested by previous studies using complement fixation, hemagglutination inhibition and neutralization tests was confirmed by the results of immunodiffusion studies. Reactions of immunologic identity were obtained between viral and soluble antigens and between antibodies produced to either of these antigens.

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