Inhibition of allogeneic lymphocyte E-rosettes induced by sera from newly diagnosed type I diabetics

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Abstract
Sera from 64 juvenile onset insulin-dependent diabetics (type I diabetics) and 30 normal subjects were tested for their ability to inhibit sheep red blood cell rosette formation (E[erythrocyte]-rosette) by normal allogeneic lymphocytes. Inhibition of E-rosette formation by greater than 20% was found with 16 (66%) sera from newly diagnosed patients, 3 (16%) sera from patients with duration of disease between 2-12 mo. and with 4 (18%) sera from diabetics with duration of disease between 1-7 yr. Only 2 (6%) control sera showed inhibitory effect. No relationship between E-rosette inhibition and islet-cell antibody presence, anti-lymphocyte antibodies occurrence, anti-HLA activity, blood glucose levels, respectively, was found. Investigation of the properties of this inhibitory factor suggests that it is different from other substances that reportedly inhibit E-rosette formation.