Near Wall Concentration Profiles of 1.0 and 2.5 μm Beads During Flow of Blood Suspensions

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Abstract
A freeze-capture method was used to determine the concentration profiles of latex beads in the flow of blood suspensions at a wall shear rate of 400 s-1 in hollow fibers of 200 μm i.d. Bead diameters of 1.0 and 2.5 μm and suspension hematocrits from 15 to 80% were used. All profiles exhibited an excess of beads in the 20 μm closest to the wall and a uniform central concentration. Near-wall excesses greater than 2.5 times the central concentration occurred with suspensions having 2.5 μm beads when the hematocrit was 15–40%. Although large near-wall excesses sometimes occurred for the small beads and higher hematocrits, the usual event was a small near-wall excess. A Mann-Whitney-Wilcoxan test showed that the group of data for 2.5 μm beads in suspensions with hematocrits ranging from 15 to 40% was significantly different from all other data (p < 0.0002). As the 2.5 μm beads approximate the average platelet, these data suggest that blood flows with physiologic hematocrits are associated with larger near-wall excesses of platelets than blood flows with elevated hematocrits.

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