Molecular Barbells

20 November 1998

journal article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 282 (5393) , 1439
https://doi.org/10.1126/science.282.5393.1439

Abstract

Dimers linked by polyethylene glycol polymers were used to bind to two sites at once, creating a ligand across rat olfactory channels and bovine photoreceptor rods and, finally, protein kinase G. Identifying ligands that can bind to multiple substrate sites with high potency and specificity could open a new approach in pharmacological research.

Keywords

LIGAND BINDING

This publication has 1 reference indexed in Scilit:

Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
Nature, 1998