Systemic Scleroderma in Mother and Daughter

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Abstract
To the Editor.— Systemic scleroderma still remains an uncommon disease of unknown cause, and the familial occurrence is very rare. We have seen two patients, a mother and a daughter in a family, with findings of systemic scleroderma. Report of Cases.—Case 1.— June 1975, a 45-year-old woman was admitted to the Hospital of the Hyogo College of Medicine with the chief complaint of hardening of her upper extremities. Fifteen years prior to admission, Raynaud phenomen of both hands and feet developed. She gradually noticed cutaneous hardness of her hands, forearms and feet, and then the shortness of her fingers and limitation of motion of her hands and fingers were recognized. Recently, she noticed slight retardation of the lips and loss of the ability to smile. Laboratory Studies.— The erythrocyte sedimentation rate (ESR) was 103 mm/hr. The WBC count was 3,900/cu mm; the RBC count, 3.07 × 106/cu mm;

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