Effect of ATSO from Coriolus versicolor on Immune Response

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Abstract
ATSO, an antitumor polysaccharide from C. versicolor, suppressed the growth of solid sarcoma 180 in mice. The additive effect of ATSO and anticancer chemotherapeutics on antitumor activity and the immune response was examined in tumor-bearing and normal mice. Delayed cutaneous hypersensitivity (DCH) of mice was depressed after implantation of tumor and treatment with antitumor chemotherapeutic drugs. ATSO inhibited the depression of DCH by i.p. or oral administration, but ATSO did not increase DCH of normal mice. The combination treatment of a low dose of ATSO and drugs promoted tumor regression significantly in mice.

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