Antibacterial Activity of Serum of Normal Men after Oral Doses of Erythromycin Propionate and Triacetyloleandomycin

Abstract
PREVIOUS studies in this laboratory have shown that, in vitro, erythromycin is four or more times as active as oleandomycin, weight for weight, against most strains of the pathogenic bacteria that were tested and found susceptible to both these antibiotics; also, after a dose of erythromycin, the antibacterial action of the serum against test strains of streptococcus and staphylococcus was several times greater than that after a comparable dose of oleandomycin, and this was true both when these antibiotics were given alone and when they were given in combination with tetracycline.1 Subsequently, triacetyloleandomycin became available2 and, although quite insoluble in . . .

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