SENSITIVITY OF ANTHROPOMETRIC TECHNIQUES FOR CLINICAL TRIALS IN ANKYLOSING SPONDYLITIS

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Abstract
To determine whether anthropometric techniques widely used for assessment of ankylosing spondylitis (AS) would be useful outcome measures in long-term clinical trials, 52 AS patients at the Royal National Hospital for Rheumatic Diseases were studied. All patients had well documented AS with a mean age of 38.1 years, and had been diagnosed for an average of 7.6 years. Measurements were taken before (B) and after (A) 3-week intensive inpatient physical therapy (PT). Short-term therapeutic effects (over 3 weeks) were significant (adjusted ppp=0.047) and cervical rotation (adjusted p=0.0l2) diminished over the course of follow-up. Therefore, 3 weeks of hospitalization with intensive physical therapy produces measurable short-term change; minute but measurable change with treatment occurs even in long-standing AS; and detectable changes in physical measurements occur over a 5-year period even in long-standing AS. Anthropometric measurements are useful outcome variables for long-term clinical trials in AS, but the potential for improvement in clinical measurements in long-standing AS is predictably small.

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