Comparison between fluctuating PEEP and conventional PEEP in dogs with lung injury induced by blood aspiration
- 1 July 1988
- journal article
- research article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 32 (5) , 369-373
- https://doi.org/10.1111/j.1399-6576.1988.tb02747.x
Abstract
It has been documented that in some patients with acute hypoxic respiratory failure the application of positive end–expiratory pressure (PEEP) may produce no improvement or even a deterioration of pulmonary oxygenation due to an increase in ventilation–perfusion mismatching. Fluctuating PEEP (F–PEEP) is a newly developed PEEP in which end–expiratory pressure (EEP) is periodically changed within a certain range. In a dog model with localized lung injury induced by the aspiration of non–heparinized blood (2 ml kg body weight‐1), F–PEEP in which the EEP was periodically changed from 0.5 to 1.5 kPa at frequencies of 10 min, and conventional PEEP with 3 different fixed EEPs, 0.5, 1.0 and 1.5 kPa (C–PEEP0.5, C–PEEP1.0 and C–PEEP1.5) were each applied for 60 min. F–PEEP produced a periodical change in Pao2 and hemodynamic variables including cardiac output, and in comparison with C–PEEP0.5, C–PEEP1.0 and C–PEEP1.5, a signficiantly greater improvement of A–aDo2 and dynamic compliance with relatively largecardiac output in the low EEP phase. These results suggest that F–PEEP is a useful mode of artificial ventilation for treating some kinds of acute hypoxic respiratory failure due to increased ventilation–perfusion mismatching.Keywords
This publication has 12 references indexed in Scilit:
- Continuous positive airway pressure improves oxygenation in dogs after the aspiration of bloodCritical Care Medicine, 1983
- Acute pulmonary failure in asymmetric lung diseaseCritical Care Medicine, 1982
- Effect of PEEP on gas exchange and pulmonary perfusion in canine lobar pneumoniaJournal of Applied Physiology, 1981
- Treatment of the Adult Respiratory Distress Syndrome with Continuous Positive Airway PressureChest, 1979
- Simple, accurate equations for human blood O2 dissociation computationsJournal of Applied Physiology, 1979
- Terminology updateCritical Care Medicine, 1978
- Variability of Effect of Positive End Expiratory PressureArchives of Surgery, 1975
- Correlation of positive end-expiratory pressure with cardiovascular performanceCritical Care Medicine, 1975
- Optimum End-Expiratory Airway Pressure in Patients with Acute Pulmonary FailureNew England Journal of Medicine, 1975
- Inhalation of Blood, Saliva, and Alcohol: Consequences, Mechanism, and TreatmentThorax, 1962