Acute Hepatitis Non-A, Non-B following Administration of Factor VIII Concentrates

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Abstract
A retrospective survey on clinical hepatitis in patients with bleeding disorders was performed. Nine episodes of hepatitis non-A, non-B occurred in 8 of 20 patients (40%) with mild hemophilia A or von Willebrand''s disease who were treated with commercial factor VIII concentrates. Only 2 episodes of hepatitis B occurred during the study period. The non-A, non-B attack rate after the 1st treatment was 40% with factor VIII concentrate obtained from large plasma pools (2000 donors) including professional plasma donors as compared to 8% after treatment with factor VIII concentrate obtained from smaller (100-250 donors) plasma pools from Scandinavian donors.