The biosynthesis of β-amyrin. Mechanism of squalene cyclization
- 1 February 1968
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 106 (3) , 659-665
- https://doi.org/10.1042/bj1060659
Abstract
1. β-Amyrin synthesized by pea seedlings in the presence of (3RS)-[2−14C,(4R)-4−3H1]mevalonic acid (for nomenclature see Cahn, Ingold & Prelog, 1956) was subjected to a series of degradations to locate the positions within the molecule of the incorporated tritium. 2. The location of five of the six labelled hydrogen atoms at C-3, C-9, C-18 and C-19 (two) confirms that the mechanism of cyclization of squalene expected from the biogenetic isoprene rule is functioning in vivo.This publication has 3 references indexed in Scilit:
- Enzymic synthesis of .beta.-amyrin from 2,3oxidosqualeneJournal of the American Chemical Society, 1967
- The stereospecific biosynthesis of plant sterols and α- and β-amyrinBiochemical Journal, 1966
- Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C—C bond formations in squalene biosynthesisProceedings of the Royal Society of London. B. Biological Sciences, 1966