Influence of Diphenylhydantoin on Isotope Release and Bone EnzymesIn Vitro

1 January 1982

journal article
research article
Published by Medical Journals Sweden AB in Acta Orthopaedica

Vol. 53 (6) , 885-888
https://doi.org/10.3109/17453678208992843

Abstract

The acute effect of diphenylhydantoin on isotope release in an in vitro system using mouse calvaries was studied. A depressive effect on bone resorption was found involving radioactive calcium as well as tritiated proline. Bone resorption and formation were further investigated by semiquantitative hístochemistry. Depressed activity of both alkaline and acid phosphatase was found, indicating a direct inhibitory effect of diphenylhydantoin on bone turnover.

Keywords

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