Association Analysis ofCFH,C2,BF, andHTRA1Gene Polymorphisms in Chinese Patients with Polypoidal Choroidal Vasculopathy
- 1 June 2008
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 49 (6) , 2613-2619
- https://doi.org/10.1167/iovs.07-0860
Abstract
Purpose. Polypoidal choroidal vasculopathy (PCV) is a major cause of serosanguinous maculopathy in Chinese patients with age-related macular degeneration (AMD). Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese. Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV.Keywords
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