Diphenylhydantoin and the cations and phosphates of electrically stimulated brain slices

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Abstract
SUMMARYSlices prepared from guinea pig cerebral cortex were incubated in bicarbonate-buffered media. Slices which were electrically stimulated at 1,000 cps lost K+ and gained Na+. Contents of ATP and creatine phosphate fell during stimulation. These effects were all diminished by 1 to 5 . 10−4 molar diphenylhydantoin. Diphenylhydantoin appears to diminish energy consumption by decreasing the downhill movements of monovalent cations that occur upon repeated membrane depolarization.

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