Experimental Production of Intramandibular Carcinoma in Mice by Mechanical Damage

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Abstract
This study demonstrated that, in mice, chronic mechanical injury to the enamel-forming epithelium of the incisor led to the development of intramandihular carcinoma. The experimental animals' own whisker hair, V2a-steel wire, and nylon thread were introduced into the alveolar socket of the mandible of young (♀ WLLf × ♂ O20)F1 mice. A total of 643 animals was used, randomly distributed over 2 control and 4 experimental groups. The penetration of foreign bodies into the alveolar socket formed a cleavage in the enamel-forming epithelium of the incisor. Accumulation of fluid in these clefts caused cysts that were covered with flattened epithelium, derived from the enamel-forming epithelium. Chronic irritation and inflammation of this metaplastic epithelium effected the formation of carcinoma from the wall of the cyst. Chemical composition of the foreign body did not influence the development of these tumors.

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