Analysis of HLA‐DRB1 alleles in Japanese patients with chronic myelogenous leukemia
- 10 January 2000
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 63 (2) , 99-101
- https://doi.org/10.1002/(sici)1096-8652(200002)63:2<99::aid-ajh8>3.0.co;2-#
Abstract
To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML, The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML. Am. J. Hematol. 63:99-101, 2000, (C) 2000 Wiley-Liss, Inc.Keywords
This publication has 10 references indexed in Scilit:
- The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual DiseaseBlood, 1998
- Association of HLA phenotype and response to interferon-alpha in patients with chronic myelogenous leukemiaLeukemia, 1998
- Peptides derived from the whole sequence of BCR‐ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytesEuropean Journal of Immunology, 1997
- HLA-DR1–Restricted bcr-abl (b3a2)-Specific CD4+ T Lymphocytes Respond to Dendritic Cells Pulsed With b3a2 Peptide and Antigen-Presenting Cells Exposed to b3a2 Containing Cell LysatesBlood, 1997
- Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptideBlood, 1996
- BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donorsBlood, 1996
- Specific human cellular immunity to bcr-abl oncogene-derived peptidesBlood, 1996