Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue
Open Access
- 1 May 2004
- journal article
- review article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (5) , 1441-1453
- https://doi.org/10.1128/aac.48.5.1441-1453.2004
Abstract
Most drugs, with few notable exceptions, such as heparin, exert their effects not within the plasma compartment but in defined target tissues into which drugs must be distributed from the central compartment. Unfortunately, a complete and lasting equilibration between blood and tissue cannot alwaysKeywords
This publication has 186 references indexed in Scilit:
- Lung clearance of intratracheally instilled 99mTc‐tobramycin using pulmonary surfactant as vehicleBritish Journal of Pharmacology, 1999
- Drug DistributionClinical Pharmacokinetics, 1998
- The synthesis of fluorine-18 lomefloxacin and its preliminary use in human studiesNuclear Medicine and Biology, 1996
- Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.Journal of Clinical Investigation, 1995
- The Importance of Pharmacokinetic/Pharmacodynamic Surrogate Markers to OutcomeClinical Pharmacokinetics, 1995
- An Application of Microdialysis to Drug Tissue Distribution Study: In Vivo Evidence for Free-Ligand Hypothesis and Tissue Binding of .BETA.-Lactam Antibiotics in Interstitial Fluids.Journal of Pharmacobio-Dynamics, 1992
- Microdialysis—principles and applications for studies in animals and manJournal of Internal Medicine, 1991
- Drug distribution studies with microdialysis III: Extracellular concentration of caffeine in adipose tissue in manLife Sciences, 1991
- The Clinical Relevance of Protein Binding and Tissue Concentrations in Antimicrobial TherapyClinical Pharmacokinetics, 1986
- Protein Binding of AntimicrobialsClinical Pharmacokinetics, 1977