Modified Directly Observed Antiretroviral Therapy Compared With Self-administered Therapy in Treatment-Naïve HIV-1–Infected Patients

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Abstract
The success of modern antiretroviral therapy for the treatment of human immunodeficiency type 1 (HIV-1) infection remains highly dependent on strict adherence to the regimen.1-3 Although rates of adherence in the developing world have recently been reported to be higher than those in the developed world,4 challenges to adherence remain in both settings.5 Unfortunately, relatively few interventions have been demonstrated to be effective.6

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