Novel bioreduction system for the production of chiral alcohols
- 28 June 2003
- journal article
- review article
- Published by Springer Nature in Applied Microbiology and Biotechnology
- Vol. 62 (5-6) , 437-445
- https://doi.org/10.1007/s00253-003-1347-y
Abstract
Chiral alcohols are useful intermediates for many pharmaceuticals and chemicals. Enzymatic asymmetric reduction of prochiral carbonyl compounds is a promising method for producing chiral alcohols. There have been many attempts to construct bioreduction systems for the industrial production of chiral alcohols. This review focuses on the establishment of a novel bioreduction system using an Escherichia coli transformant co-expressing genes for carbonyl reductase and cofactor-regeneration enzyme. This bioreduction system could be useful as an all-purpose catalyst for asymmetric reduction reactions.Keywords
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