THE CONTROL OF EXPERIMENTAL INFECTIONS OF THE ANTERIOR CHAMBER AND OF THE VITREOUS BY SUBCONJUNCTIVAL AND RETROBULBAR INJECTIONS OF CRYSTALLINE PENICILLIN IN DOSES OF 1,000,000 UNITS
Open Access
- 1 December 1948
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 32 (12) , 873-878
- https://doi.org/10.1136/bjo.32.12.873
Abstract
Staphylococcus aureus (50,000 organisms)in 0.05 ml. of saline, injd. into the rabbit''s anterior chamber, caused a destructive panophthalmitis within 48 hrs. If subconjunctival or retrobulbar penicillin (1,000,000 U.) was given 4 hrs., and repeated 24 hrs., after introduction of organisms, the infection cleared rapidly; but if therapy was not started until 24 hrs. after onset of infection, recovery was slow and often incomplete. Intravitreal injn. of the organisms caused a destructive panophthalmitis unless the penicillin was admd. within 4 hrs. of the infection. On the whole, the subconjunctival route was more effective then the retrobular one.Keywords
This publication has 2 references indexed in Scilit:
- INTRAVITREAL INJECTION OF PENICILLIN: STUDY ON THE LEVELS OF CONCENTRATION REACHED AND THERAPEUTIC EFFICACYBritish Journal of Ophthalmology, 1948
- Pure Penicillin in OphthalmologyBMJ, 1946