The Action of Morphine and Morphine-Like Analgesics Applied on the Intraluminally Peristaltic Reflex of the Isolated Guinea Pig Ileum

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Abstract
Morphine and morphine-like analgesics inhibit peristalsis of the isolated guinea pig ileum, when introduced into its lumen. Their effects were parallel to their relative analgesic potencies. Since suitable doses of morphine did not inhibit the responses to nicotine and to 5-HT, it is thought that the inhibitory action of morphine and related drugs, involves the afferent part of the peristaltic reflex. Peristalsis, previously abolished by intraluminal morphine, can be restored by 5-HT by the same route. That the inhibitory action of the intraluminal morphine upon the peristalsis may be caused, at least partly, by its antagonism towards intrinsic 5-HT and may take place on the same mucosal receptors, is discussed.

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