THE EFFECT OF CHOLESTYRAMINE ON SERUM LIPIDS AND PLATELET AGGREGATION OF HYPERCHOLESTEROLEMIC CHILDREN (TYPE 11A) WHILE ON HIGH LINOLEIC ACID DIET

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Abstract
25 children with familial hypercholesterolemia (type II A) were treated with cholestyramine or placebo in a cross over study during 2 periods of each 10 weeks. The medication was added to a high linoleic acid diet, which had been started at least 1 year earlier. Serum lipids and platelet aggregation were investigated at the end of the 2 periods. On cholestyramine, serum cholesterol levels decreased significantly, whereas the linoleate and oleate content of cholesterylesters and serum triglycerides did not change systematically. Platelet aggregation time, measured with a filtragometer, did not systematically change either.