Stress-Induced Suppression of Immunity in Adrenalectomized Rats
- 23 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4617) , 1301-1304
- https://doi.org/10.1126/science.6612346
Abstract
Stress-induced suppression of lymphocyte stimulation by phytohemagglutinin was demonstrated in isolated lymphocytes and in cultures of whole blood from adrenalectomized rats. The results demonstrate that corticosteroid independent mechanisms participate in the suppression of lymphocyte function by stressors. Stress-induced lymphopenia, however, was found to be adrenal dependent, indicating that the modulation of immunity by stress is complex and multidetermined.Keywords
This publication has 18 references indexed in Scilit:
- A simplified method for assessing PHA induced stimulation of rat peripheral blood lymphocytesJournal of Immunological Methods, 1982
- Immunosuppressive Effects of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-DeazaadenosineJournal of Immunopharmacology, 1982
- Psychoneuroendocrine Influences on Immunocompetence and NeoplasiaScience, 1981
- Comparison of a Simplified Whole Blood and Isolated Lymphocyte Stimulation TechniqueImmunological Communications, 1981
- Adrenal involvement in conditioned immunosuppressionInternational Journal of Immunopharmacology, 1979
- Subcutaneous implantation method for chronic glucocorticoid replacement therapyPhysiology & Behavior, 1979
- Stress-Induced Modulation of the Immune ResponseScience, 1977
- Human lymphocyte subpopulations. Effect of corticosteroids.Journal of Clinical Investigation, 1974
- Stress and the Hormonal Regulation of the Immune Response in MicePsychotherapy and Psychosomatics, 1974
- Inhibition of lymphocyte recirculation by stress and corticotropinCellular Immunology, 1972