Frequency analysis of cytolytic T cell precursors (CTL‐P) generated in vivo during lethal rabies infection of mice. I. Distinction of CTL‐P with different interleukin 2 sensitivity
- 1 January 1982
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 12 (6) , 519-523
- https://doi.org/10.1002/eji.1830120613
Abstract
The aim of this study was to determine the number and state of activity of cytolytic T lymphocytes (CTL) and their precursors (CTL-P) present in vivo during the early stages of viral infection. The local response to lethal infection with rabies virus was used as a model system that is not accessible to analysis by secondary activation in vitro. The local response to alloantigen served as a control. Experimental protocols were established that allow frequency estimates of in vivo antigen-triggered CTL-P. Data allow a distinction between CTL-P activated in vivo by alloantigen and viral antigen with respect to their different capacity to utilize T cell growth factors (inter-leukins). In vivo alloantigen-primed CTL-P generate, in vitro, an active effector progeny in the presence of interleukins of xenogeneic origin, whereas the majority of virus-specific CTL-P, in spite of considerable expansion in vivo, fail to generate CTL in vitro unless antigen is added.This publication has 22 references indexed in Scilit:
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