Diffuse hypertrophy of the cerebellum

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Abstract
This study describes a further case of diffuse hypertrophy of the cerebellum in a 25-year-old woman. There was a doubtful history of slight unilateral ataxia over 20 years or more, with eventually an episode of raised intracranial pressure. The lesion, in the postero-supero-lateral quadrant of the left cerebellar hemisphere, was incompletely removed at operation. Biopsy showed metamorphosis of the granular layer into larger ganglion cells, with thickening and hypermyelination of the molecular layer, and narrowing of the central white matter. The patient recovered with little or no disability, and returned to full-time employment in a responsible post.