QUANTITATIVE STUDIES ON THE LIPOLYTIC RESPONSE OF HUMAN SUBCUTANEOUS AND OMENTAL ADIPOSE TISSUE TO NORADRENALINE AND THEOPHYLLINE

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Abstract
Subcutaneous and omental human adipose tissue, obtained at surgery, has been incubated in vitro, and the release of glycerol into the medium has been determined.The addition of 0.1 μg of noradrenaline stimulated the glycerol release. Maximal stimulation was obtained with 1 μg of noradrenaline.Theophylline in a concentration of 2.5 times 10‐4 M increased lipolysis. Maximal effect was obtained with 10‐2 M concentration, and higher concentrations tended to inhibit the release of glycerol.When maximal stimulation of lipolysis was induced with these two agents there was a tendency, most pronounced for subcutaneous tissue, towards greater lipolysis with theophylline than with noradrenaline.Subcutaneous and omental adipose tissue had similar basal release of glycerol. The omental tissue, however, had a significantly higher glycerol release than the subcutaneous tissue when they were maximally stimulated with either noradrenaline or theophylline.