Liquid Chromatographic Evaluation of a New Chiral Derivatizing Reagent for Enantiomeric Resolution of Amine and Alcohol Drugs

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Abstract
A new chiral resolving reagent N-(p-toluenesulfonyl)prolyl isocyanate(TSPI) was prepared with a very practical method and evaluated for liquid chromatographic resolution of amine and alcohol enantiomers via diastereomeric derivatization. This procedure is rapid and convenient, with good separation, few by-products. Expected structures of the derivatives were confirmed by mass spectra. Ordinary normal phase and the mobile phase of petroleum ether were used.
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