The pig histocompatibility system SLA: Serological study on a group of antigenic specificities

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Abstract
An analysis of a group of class I SLA reagents which were highly correlated within 1 cluster in a previous analysis is presented. Further population and family studies and selected purification of several of these reagents led to the identification of 4 distinct specificities, e.g., SLA A 15, B 18, C 1 and A 16. Three of them, SLA A 15, B 18 and C 1, are actually in strong linkage disequilibrium and represent the main SLA haplotype in the Large White breed. SLA A 16 is present essentially in the Landrace breeds. SLA A 16 displays a strong cross-reaction with SLA A 15 and there is another specificity in linkage disequilibrium with SLA A 16 which cross-reacts with SLA B 18. The strong linkage disequilibrium and the high degree of cross-reactivity among the allelic products of the SLA complex explain the failure to detect the diversity of reagents in previous studies.