Anaphylaxis in the Dog

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Abstract
The dog releases histamine, but not 5-hydroxytryptamine in anaphylactic shock. Localization of histamine (and 5-hydroxytryptamine) in various organs is listed. In dogs sensitized to 2 antigens, shock cannot be elicited by the 2nd antigen, if it is injected after reaction by the 1st one. Compound 48/80 and other histamine releasers, however, will still release histamine from the tissues. If compound 48/80 is injected during the period of sensitization, it will prevent anaphylactic shock even if it is given as early as 7 days before challenge. Anaphylactic shock will release histamine much more effectively from the liver than from the skin or ears. The relations of these findings to the mast cells are discussed.

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