Recombination between the dfrA12 -orfF- aadA2 Cassette Array and an aadA1 Gene Cassette Creates a Hybrid Cassette, aadA8b

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Abstract
Homologous recombination between closely related gene cassettes, such as aadA1 and aadA2 , which are 89% identical, can create hybrid cassettes and hybrids of existing cassette arrays. A new cassette array, dfrA12 -orfF- aadA8b , which was created by such a recombination event occurring within the aadA2 cassette in the dfrA12 -orfF- aadA2 array, has been identified.