NEW EMBO MEMBER'S REVIEW: Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

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Abstract
Changes in cell–cell and cell–matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.