STUDIES OF INFLUENZA IN DOGS. I. SUSCEPTIBILITY OF DOGS TO NATURAL AND EXPERIMENTAL INFECTION WITH HUMAN A2 AND B STRAINS OF INFLUENZA VIRUS12

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Abstract
Dogs four to ten months of age were exposed to low egg passage suspensions of recent types A2 or B human influenza isolates. Exposure was by intranasal instillation, aerosol, intranasal instillation plus intravenous inoculation, or by contact with dogs thus infected. Virus was recovered from nasopharyngeal and throat secretions from dogs directly exposed for as long as five days following exposure. Anti-S and anti-V antibody titers were produced by these dogs and in some instances persisted at high levels for as long as 14 months. There was no evidence of transmission of virus from infected to contact dogs. Four out of 600 serum specimens randomly obtained from various geographic areas throughout the United States contained anti-V CF titers against a human type B strain of influenza virus.