Spontaneously Hyperglycemic Laboratory Animals - Models of Human Diabetes-Syndrome?

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Abstract
The obvious similarities to human diabetes syndromes have often been pointed out especially in those syndromes of small laboratory animals. In all these conditions, inappropriate hyperglycemia is present and either results from an elevated food intake or a more efficient utilization of fuel. Hyperphagia, a characteristic of most spontaneously hyperglycemic animals frequently leads to obesity. Animals with spontaneous hyperglycemia can be classified as animals with ketosis and animals without ketosis. This classification only indicates whether insulin concentration is sufficient or insulin resistance is a contributing feature. Since there are a variety of metabolic disorders represented by the various animal models and strains, more precise characterization is necessary. To aid investigators in the choice of suitable animal models the characteristics of the most used animals in diabetes research are presented and the strain specific features indicated.

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