Semisynthetic penicillins. A structure-activity study of a new series of acyl amino acid-pyridone and pyrimidone amoxicillin analogs.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (7) , 862-868
- https://doi.org/10.7164/antibiotics.34.862
Abstract
The synthesis and biological activities of a series of 12 new semisynthetic penicillins is described. These compounds consisted of acylated amino acid analogs of 6-substituted-1,2-dihydro-2-oxonicotinic acid and 2-substituted-3,4-dihydro-4-oxo-5-pyrimidinecarboxylic acid attached to amoxicillin. The effect of the amino acid substituent, chirality of amino acid and acyl function on biological properties is discussed.This publication has 1 reference indexed in Scilit:
- CI-867, a new broad-spectrum semisynthetic penicillin.The Journal of Antibiotics, 1978