Nerve regeneration in exogenous cerebral ganglioside‐treated rats

Publisher Website
Google Scholar
Abstract
Intraperitoneal injection of 50 mg/kg of exogenous cerebral gangliosides resulted in a statistically significant (23%) increase (compared with saline‐injected controls) in the tetanic isometric tension of the rat plantaris muscle 7 days after section of the fourth lumbar root (L4). In a second experiment, intraperitoneal‐injected exogenous gangliosides were found to have no effect on axonal regeneration following cryoinjury to the sciatic nerve. These results lead to the possibility of an early enhancement of muscular collateral sprouting in partially denervated muscles under an intraperitoneal‐injected ganglioside mixture treatment.