Correction of Murine β-Thalassemia by Gene Transfer into the Germ Line
- 12 September 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 233 (4769) , 1192-1194
- https://doi.org/10.1126/science.3461564
Abstract
A murine beta-thalassemia was corrected by the transfer of cloned beta-globin genes into the mouse germ line. The cloned mouse beta maj-globin gene or the cloned human beta-globin gene was introduced into mice deficient in beta-globin synthesis because of a deletion of the beta maj-globin gene. Both introduced genes produced functional beta-globin chains, leading to a reduction in one case, and elimination in another case, of the anemia and associated abnormalities of the red blood cells.This publication has 21 references indexed in Scilit:
- The ethics of human gene therapyNature, 1986
- Gene Expression in Mice After High Efficiency Retroviral-Mediated Gene TransferScience, 1985
- Functional expression of a microinjected Edα gene in C57BL/6 transgenic miceNature, 1985
- Correcting an immune-response deficiency by creating Eα gene transgenic miceNature, 1985
- Specific expression of a foreign β-globin gene in erythroid cells of transgenic miceNature, 1985
- Partial correction of murine hereditary growth disorder by germ-line incorporation of a new geneNature, 1984
- Expression of a Retrovirus Encoding Human HPRT in MiceScience, 1984
- Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouseNature, 1984
- Gene therapyNature, 1982
- GENETICS OF MOUSE HEMOGLOBINS *Annals of the New York Academy of Sciences, 1974