Effects of Pituitary Grafting and CB-154 Treatment on the Growth of Prostates in Mice

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Abstract
Implantation of a single anterior pituitary into the ventral prostates of intact mice induced a significant increase in the weight and the area occupied by the glands of ventral prostates associated with the elevation of circulating prolactin. However, the growth of the dorsolateral prostates was not augmented by the treatment. Injection of CB-154 (bromocriptine-mesilate) during the developmental stage of the prostatic tissue (3–5 weeks of age) suppressed the weight increase of ventral prostates but not dorsolateral prostates in intact mice. All results suggest the different response of the ventral and the dorsolateral prostates to prolactin. Pituitary grafting produced hyperplastic lesions in the prostates, however, modified little the effects of carcinogen on the tissue.