Poorly differentiated, neuron-specific enolase positive round cell tumor with two translocations t(11;22) and t(21;22)
- 1 November 1987
- Vol. 60 (9) , 2219-2223
- https://doi.org/10.1002/1097-0142(19871101)60:9<2219::aid-cncr2820600919>3.0.co;2-z
Abstract
The authors describe a highly malignant, disseminated round cell tumor originating in the ninth rib of a 14-year-old boy. Extensive studies by means of light and electron microsocopic examination, histocytochemistry and immunocytochemistry and cytogenetic analysis revealed an undifferentiated, neuron-specific enolase positive round cell tumor with a unique karyotype: 45,XY,-21,t(11;22)(q23;q11), der(22)t(21;22)(q11.2;p11). Thus, despite the absence of definite morphologic features, such as Homer-Wright rosettes, neurosecretory granules and cytoplasmatic processes, these findings suggest a neuroectodermal origin of this bone tumor.This publication has 27 references indexed in Scilit:
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