Inhibition of Erythropoietic Effects of Hormones by Erythropoietin Antisera in Mildly Plethoric Mice.
- 1 October 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 126 (1) , 97-100
- https://doi.org/10.3181/00379727-126-32375
Abstract
Summary Antisera to erythropoietin (Anti-ESF) was found to block completely the erythropoietic effects of 3,5,3′-triiodothyronine (T3), ACTH, and testosterone in mildly plethoric mice. The effects of T3, ACTH, and testosterone were also markedly dampened by increased plethora. The hormones studied increased radioactive iron in red cells of mildly plethoric mice without producing a significant alteration in plasma iron. These findings indicate that ACTH, testosterone and T3 stimulate erythropoiesis indirectly by increasing the elaboration of endogenous erythropoietin, or else they require a certain level of erythropoietin in the recipient animal for their erythropoietic effects.Keywords
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